DISTINCT BRAIN ACTIVITY PATTERNS ASSOCIATED WITH TRADITIONAL CHINESE MEDICINE SYNDROMES: A TASK-FMRI STUDY OF MILD COGNITIVE IMPAIRMENT

Distinct brain activity patterns associated with traditional Chinese medicine syndromes: a task-fMRI study of mild cognitive impairment

BackgroundAbnormalities in brain activity patterns during episodic memory tasks have been inconsistently reported in amnestic mild cognitive impairment (aMCI) patients using functional magnetic resonance imaging (fMRI).This study applied traditional Chinese Maternity Tops medicine (TCM) syndrome differentiation to categorize aMCI patients into dist

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Effect of TP53 deficiency and KRAS signaling on the bioenergetics of colon cancer cells in response to different substrates: A single cell study

Metabolic reprogramming is a hallmark of cancer.Somatic mutations CORRECTOR in genes involved in oncogenic signaling pathways, including KRAS and TP53, rewire the metabolic machinery in cancer cells.We here set out to determine, at the single cell level, metabolic signatures in human colon cancer cells engineered to express combinations of activati

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In Vivo Imaging of Xenograft Tumors Using an Epidermal Growth Factor Receptor-Specific Affibody Molecule Labeled with a Near-infrared Fluorophore

Overexpression of epidermal growth factor receptor (EGFR) is associated with many types of cancers.It is of great interest to noninvasively image the EGFR expression in vivo.In this study, we labeled an EGFR-specific Felt Decoration Affibody molecule (Eaff) with a near-infrared (NIR) dye IRDye800CW maleimide and tested the binding of this labeled m

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